I have a weird problem (running Windows 10).
My left mouse button doesn't work on icons in the system tray and my right mouse button doesn't work in the toolbar. So for instance if I left click on the wireless internet control in the system tray nothing happens. Mousing over it gives me the tips and right clicking works, but the left click doesn't. A similar (but of course opposite) problem happens down in the toolbar. A left mouse click on Chrome starts it up but right mouse click doesn't show the incognito etc options.
I have the same issue if I use the laptop mouse or a wireless mouse.