Yes. It is possible to acquire the token using the HTTP request directly for the Resource Owner Password Credentials flow.
We can use the Fiddler to capture the request to see the detail parameter required. And here is a code sample to use this flow to get the access token for the native client app:
string resrouce = "https://graph.windows.net";
string clientId = "";
string userName = "";
string password = "";
HttpClient client = new HttpClient();
string body = String.Format("resource={0}&client_id={1}&grant_type=password&username={2}&password={3}", Uri.EscapeDataString(resrouce), clientId, Uri.EscapeDataString(userName), Uri.EscapeDataString(password));
StringContent sc = new StringContent(body,Encoding.UTF8, "application/x-www-form-urlencoded");
var resoult= client.PostAsync("https://login.microsoftonline.com/xxxx.onmicrosoft.com/oauth2/token", sc).Result.Content.ReadAsStringAsync().Result;
And if you are working with web app, we need to append the client_secret parameter in the body.