What density of satellites in LEO is permissible before a single collision has a reasonable chance of triggering the catastrophic destruction of everything in orbit? How many orders of magnitude are we below this level presently--is this a practical concern that limits our ability to utilize space in the long run?
(The reason a single collision could result in near-complete destruction is that when satellites collide, or are badly damaged, they release many pieces of debris that may badly damage other satellites and cause further collisions. If the probability of collision with debris (before deorbiting) times the number of pieces of debris produced by collision is greater than one you end up in a supercritical regime as with viral pandemics and nuclear meltdowns/explosions.)