Synthesising information from these (1 2) reports to congress:
From the 2015 source:
According to project officials, there are over 100 different ways that
a failure could occur, referred to as single point failure modes, across
hundreds of individual items in the observatory. Each of these could
result in a loss of minimum mission objectives, and thus needs to be fully
tested and understood. Nearly half of the single point failure modes
involve the deployment of the sunshield.
From the 2020 source:
The project found that certain bolts, determined to be deficient on
another Northrop Grumman program, were used during the
construction of the observatory. A study of this issue found that the
bolts used did not meet specifications and could pose a mechanical
strength risk. The unused bolts have been identified and isolated, but
501 were installed in the observatory. NASA is performing strength
testing to determine if the bolts are strong enough, but some of the
deficient bolts may need to be replaced, pending the findings of these
tests.
The project reported in August 2019 that grounding straps on the
spacecraft’s momentum flap came loose during vibration testing. This
flap will act as balance against solar pressure that could cause
unwanted movement of the observatory while in orbit. Observatory level vibration testing cannot begin until the flap is removed, repaired,
and replaced aboard the spacecraft.
In September 2019, the project found that a non-explosive actuator on
one of its membrane retention devices did not fire as planned. These
devices, which help to unfurl the sunshield of the spacecraft, are
supposed to be electrically redundant, but only one of the two
mechanisms used to fire the actuator worked during the test. The
program reports that there are approximately 180 actuators on the
JWST and the failure of any one of these actuators could result in the
total loss of JWST science mission objectives. If the redundancy for
the actuators is reduced, it would have a major impact on system
reliability.