Even spacecraft that are designed and optimized for a single mission need to be carefully balanced experimentally, and have ballast added before flight.
- Why did New Horizons have to be spin-balanced to grams-level precision? (With quarters!)
- Balancing Perseverance Mars Rover; couldn't they just "move stuff around a little" rather than add 6+ kg of dead weight?
- How to find the moment of inertia of the Viking capsule?
The Space Shuttle was reusable and had a comparatively short turn-around time, each time with a different payload.
Was the shuttle's mass distribution or at least its moments of inertia measured pre-flight? If so was ballast ever added then to balance it?

Fraley, J. G.and that name along with the term "mass properties" is found on original page number 272 of this Engineering Innovations article: https://www.nasa.gov/centers/johnson/pdf/584733main_Wings-ch4g-pgs270-285.pdf – uhoh Apr 28 '20 at 21:56