tl;dr: What is the density of "space dust" or micrometeorites in interstellar space, and how likely is it that a tiny interstellar craft could avoid hitting any?
In a future time we will likely figure out how to accelerate a usable space probe to 0.1c and shoot it to Alpha Centuri, considering there is already serious work being done on this topic.
If such a craft hits a particle, even something smaller than a grain of sand, it will probably be game-over for it (0.5*0.67mg*(0.1c)^2 = 300,000,000 joules, which is about a ton of TNT).
Considering that there are a lot of micrometeorites, at least around earth, and navigation at 0.1c is fairly difficult, what would be the chance of a space probe making it through interstellar space?