I've just deployed an update to an existing ASP.NET MVC3 site (it was already configured) and I'm getting the IIS blue screen of death stating
HTTP Error 500.0 - Internal Server Error
The page cannot be displayed because an internal server error has occurred.
However; there is nothing showing up in the Application Event Log where I would expect to see a (more) detailed description of the entry.
How can I go about diagnosing this issue?

I suspect something is going wrong with the AppDomain unload that occurs after deployment. Out of curiosity, are you running antivirus in your production environment?
Does an IIS reset solve the issue (until the next deployment)?
– ShadowChaser Feb 21 '13 at 16:17