Regarding bar deformation:
Bars do bend, and specialized deadlift and olympic lifting bars are designed to bend significantly when they are lifted. This is referred to as "whip" and allows the lifter to "take out slack" on the bar. This has two primary effects on deadlift, or lifts done off of the floor:
The natural flexibility built into these bars allows the lifter to take more time to achieve an output force equal to the weight they are trying to lift. This is physiologically important because there are reflexes that inhibit force production. These reflexes are triggered by the deformation of tendons, and tendons deform more when the rate of change of force (jerk) on the external object is greater because in addition to the force of raising the weight (mg), the lifter must accelerate the mass of the "weight" (ma) and the acceleration on the center of mass is decreased if the bar allows the lifter to take out slack. This means that the lifter may be able to achieve the force needed to get the bar off the ground without having his or her tendons stretch to a point that will cause an inhibitory signal.
Taking out slack raises the center of mass of the "weight" without requiring the lifter to exert enough force to break contact with the ground. It also lowers the center of mass relative to the lifter's hands. This means that the lifter will not have to raise the center of mass by as great a distance to complete the lift. It also means that the lifter will not have to exert enough force to equal the weight of the bar until they are in what is usually a better bio-mechanical position to exert force.
In both of these cases, a and b, loading the bar small to large will increase the degree of deformation that these specialized bars will experience, furthermore, loading a high whip bar with more weight further out can have a significant affect on how hard it is to lift the bar. There will be a similar but smaller effect on more rigid bars.