Sensor dimensions don't matter.
F-stop is shorthand for "fractional" and what it's a fraction of is the lens focal length and the diameter of the iris and the real calculation is simply the lens focal length \$f\$ divided by aperture diameter \$D\$ (that is, \${f\,/\,D}\$).
50 mm lens with an iris 25 mm across is at f/2.
So in your case, if you know the radius then it's simply
$$ \text{f-number} = \frac{\text{focal length}}{2\,\times\,\text{radius}} $$
Note regarding measurements: Scientific pursuits are usually done in metric, so most things with lenses are measured in mm and therefore the diameter is mm. (The fraction remains the same since it's just a number and the mm cancels out in the division.) Lenses in the early part of last century were sometimes measured in inches, and because the units carry through in the calculations the answer would also be in inches.