The basic answer is that no, no one makes a large-control DSLR.
If your friend is satisfied with having the camera pre-set up and then leaving it in automatic mode, a cable release for the shutter may be an option. This may be unsatisfactory if he wants more control — or if he would have difficulty with the camera's power switch.
One could use a camera with a computer tethering interface and a laptop. This could be used with existing interface-accessibility software, or, theoretically someone could develop custom camera control software meant to be easily used with a variety of specialized input devices
While there's a lot of software that does tethered control, I'm not aware of any that is specifically written with special accessibility needs in mind.