Is there an algorithm that, given polynomials $P(x)$ and $Q(y)$ with integer coefficients, decides whether there exists integers $x$ and $y$ such that $\frac{P(x)}{Q(y)}$ is an integer?
This is a special case of a more general question to decide the existence of integer points of a rational function $R(x,y)=\frac{P(x,y)}{Q(x,y)}$. This looks difficult in general, because if $Q=P^2+1$, then $R(x,y)$ is integer only if $P(x,y)=0$, and there is no known algorithm to decide the existence of integer solutions to this equation. However, one may ask a relaxed question: assuming that we can solve equations $P(x,y)=a$ and $Q(x,y)=a$ for every integer $a$, can we then decide whether $\frac{P(x,y)}{Q(x,y)}$ can be an integer? This would surely answer the original question.