The Byzantine Empire was always a Hellenic oriented empire...from its earliest foundations dating to Constantine and Helena, to the final days of the Paleologos Dynasty. For over 1000 years, Constantinople, was the Capital of a Medieval Greco-Christian Empire.
With regard to the Roman nature of the Byzantine Empire, it is true that during the first few centuries, the Byzantine Empire was governed by a mixture of Greek and Roman Emperors-(there were even a few Illyrian Emperors, as well as Emperors who of mixed Illyrian ethnic descent, such as Constantine and Justinian). While Latin was communicated throughout the Administrative, Juridical and Aristocratic classes during the Empire's early years-(i.e. early 300's-600 AD/CE), the Byzantine Empire's association and identification with the Greek language, as well as with Greece and Asia Minor and the legacy of Hellenism..... never really disappeared.
One of the more distinguishing characteristics of Byzantium's Greek identity-(from its earliest beginnings), was also its own uniquely distinct version and practice of the Christian religion. The Byzantines practiced an Eastern type-(or rite) of Christianity in a variety of ways. The Supreme Religious Leader of The Eastern Rite/Byzantine Church, was and is....The Patriarch of Constantinople-(who is viewed as the Heir to Saint Andrew). The Byzantine Empire had and still has...Middle Eastern based Patriarchates in Jerusalem and Alexandria, Egypt. Theologically speaking, the Byzantine Liturgy, as well as its style and tone of hymn singing differs from the Latin mass. The Byzantine style of ecclesiastical architecture places a heavy emphasis on iconography-(as well as the simultaneous forbiddance of statuary imagery). But with regard to its Hellenic nature, the Byzantine Church routinely used the Greek language during Church services and the Byzantine Empire pioneered some of the earliest Monasteries in the Middle East and Greece proper. Intellectually speaking, the Byzantines, meticulously preserved and commented on their centuries old textual "Greek Classics" at its Library and University in Constantinople...(which were destroyed by Papal directed Latin Crusader sieges during The Late Middle Ages).
But what truly distinguishes the Byzantine Church from the Western Church, was its emphasis on the mystical, transcendental and spiritual nature of Jesus Christ...from the Anunciation, to the Resurrection and Ascendancy.
These theological, religious, intellectual and historical characteristics of the Byzantine Christian civilization did not start at some random point in the Middle Ages.....they existed from the earliest years of the Empire.
Now, it should be noted that politically speaking, during the first decade of the 600's AD/CE, the Emperor Heraclius-(if my memory is correct), essentially removed all Latin and Roman remnants of the Byzantine Bureaucracy and Culture and began a widespread system of Hellenization throughout the Empire, thereby identifying, associating and distinguishing The Byzantine Empire, as a Greek and Eastern rite Empire which was noticeably separate and distinguishable from its Papal neighbor in Rome. It was from the 600's onward that the Byzantine Empire became-(both territorially and culturally), an increasingly Eastern Christian empire with key geopolitical interests in lands to the North, and especially to the East of Constantinople-(as well as Greece proper).
It is true that the Byzantines traveled westward and had occupied a sizable portion of the Eastern Italian coast, as well as much of Sicily and it is also true that the Byzantines had traveled southward whereby they occupied parts of North Africa. However, these territorial occupations existed during the early years of the empire and due to the Islamic conquest of North Africa, as well as the rise of Papal power within Italy proper, the Greco-Byzantine Christians, from the 600's onward, looked increasingly Northward and especially Eastward.