According to this quite thorough answer :
Is re-projection needed from SRID 4326 (WGS 84) to SRID 4269 (NAD 83)?
the crs EPSG:4326 and EPSG:4269 are slightly different, due to a difference in one of the semi-axis of the reference ellipsoids (small difference) and also to a shift in the origin of the NAD83 Datum used in 4269.
However, when using pyproj (python 3.8.8 and pyproj 3.0.1 on windows) to project a point from EPSG:4326 to EPSG:4269, I obtain the exact same lat/lon :
from pyproj import CRS, Transformer
from shapely.geometry import Point
from shapely.ops import transform
crs_4326 = CRS("EPSG:4326")
crs_4269 = CRS("EPSG:4269")
transformer_4326_to_4269 = Transformer.from_crs(crs_from=crs_4326, crs_to=crs_4269).transform
p = Point(-118,33) # some position in California
p1 = transform(transformer_4326_to_4269, p)
print(p) # returns POINT (-118 33)
print(p1) # also returns POINT (-118 33) !
I am quite confused as I was expecting a (rather small) difference.