I bet Mom once with Lazarus. I beat Mom again with Azazel and the game ended there and I didn't unlock the Womb. I also collected 60 coins and didn't unlock Cain. I'd better mention that both times I beat Mom I had typed in seeds I saw from streamers/youtubers.
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http://gaming.stackexchange.com/q/197536/87579 – pinckerman May 09 '15 at 13:05
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Having used seeds is exactly your problem. You can't unlock anything when using seeds.
Arperum
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