I have both Crabs against Humidity and Guards against Insanity. They can be mixed with Cards against Humanity. They have different backs but that is not a real problem.
Personally, I think the original (and the original expansions 1 to 6) are better. I use the following arguments:
- A lot of the unofficial expansion cards are probably targetted to the younger public and as such have a lot of references to sex and nudity.
- Some white cards have a limited use.
- A lot of black cards have 2 or three blanks so you run out of white cards fast.
- Some cards are almost duplicates of cards from the original series.