Biology Stack Exchange
Biology Stack Exchange

Questions tagged [systems-biology]

An interdisciplinary area of study in the life sciences with a focus on complex interactions and large networks of biological molecules and processes.

A system is defined as an assembly of mutually interacting components which, based on the dynamics of the interactions, performs specific functions. Therefore one of the main features of systems biology is to understand the input-output characteristics of a biological system by integrating the fields of experimental biology and applied mathematics.

For a basic yet thorough introduction please read Introduction to Systems Biology -by Uri Alon

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Are the inverse problems of Systems Biology impossible to solve?

I have heard Sydney Brenner give a talk [0] on how the entire program of Systems Biology is suspect because, according to him, a chap named Hadamard showed that inverse problems are impossible to solve, or something to that effect. I find it…
Joebevo
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Can a protein falling below a threshold trigger another response?

Is it possible that the falling of the concentration of a protein below a threshold triggers the release or production of another protein?
Peter123
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Does this equation have a typo? (Systems Biology, singular value decomposition)

I'm reading a systems biology paper, and I'm suspecting there's a typo in an equation, but I want to make sure. The article is "Systemic metabolic reactions are obtained by singular value decomposition of genome-scale stoichiometric matrices."…
jarlemag
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Can any systems biology model be complete?

In systems biology, models identify the primary actors in the body system, but can any model which does not include all secondary actors be said to be complete? The current sysbio paradigm is to identify and study biological subsystems. However…
Jamie
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Bistability vs bimodelity

In a systematic viewpoint, bistability refers to the existence of two stable equilibriums for a biological system. But, I don't understand the difference between bistability and bimodality. In both cases, the system should have two different…
A.Loc
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