14

What databases are available for gene regulatory network graphs starting from a given gene? For example, starting from p53 gene, where can I find a gene regulatory network image that can be exported or embedded to another website?

Michael Kuhn
  • 4,090
  • 24
  • 39
yahoo301503
  • 744
  • 3
  • 10

3 Answers3

10

For a free resource, try GenMAPP. Commercial products like Ingenuity Pathway Analysis do the same thing with prettier graphics and a curated approach to network-building, but access can be expensive if you're not affiliated with an institution that will foot the bill.

Transcriptase
  • 617
  • 4
  • 11
8

If you can't afford ingenuity, KEGG has branched out into regulatory networks as well. Here's the link to their version of the pathway.

http://www.genome.jp/kegg/pathway/hsa/hsa04115.html

Its free to use as a reference and for academic research.

shigeta
  • 28,244
  • 2
  • 60
  • 120
  • 1
    How did you get to this page? I want exactly the same thing for other genes but I keep winding up at pages that look like this: http://www.genome.jp/dbget-bin/www_bget?ko:K02583 and don't know where to go – Slavatron Dec 11 '14 at 19:02
  • i can click on 'pathway menu' and then use the box to search for my genes and get more diagrams like this one. – shigeta Dec 17 '14 at 15:41
3

I highly recommend you to visit Pathguide to get a sense of how vast is the catalog of Pathway Databases. Looking into the category Pathway Diagrams or in Transcription Factors / Gene Regulatory Networks should help in your task.

I would start by looking at these DataBases:

  • GeneMania
  • BioCarta
  • WikiPathways
  • Reactome

If you are working with a species other than human, perhaps you'll find a more suitable database in PathGuide.

Good luck!

PS: Sorry New user limitations impede me to post more than two links :/

Community
  • 1
Angel Garcia Campos
  • 131
  • 4