What are the various types of protein-protein interactions

Asked Mar 12 '12 at 23:20

Active Mar 13 '12 at 11:26

Viewed 1,327 times

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I understand there are a number of protein-protein interactions, but what types of interactions exist? and what are the characteristics of them?

edited Mar 13 '12 at 11:26

asked Mar 12 '12 at 23:20

harpalss

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Characteristics? They happen between proteins. – Konrad Rudolph Mar 12 '12 at 23:41
characteristics of the interaction type, i.e, what makes a hydrophobic interaction? – harpalss Mar 13 '12 at 00:20
I would suggest asking "what are the various types of protein-protein interactions" – bobthejoe Mar 13 '12 at 07:33

1 Answers1

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There are so many types of protein-protein interactions via various domains, such as SH2 binding (in RTK signaling), Pleckstrin Homology domain (involved in signaling) among others. This site gives a nice list: http://pawsonlab.mshri.on.ca/index.php?option=com_content&task=view&id=30&Itemid=63

Of course, protein-protein interactions rely on the premises of basic biochemistry:

van-der waals interactions (at the most basic level)
Electrostatic interactions
"Lock and Key" model: Some proteins have specific binding pockets for domains of other proteins
Induced fit

There are many ways to study protein-protein interactions, including, but not limited to

Pull-down assays
2D SDS-PAGE / MS
Yeast two-hybrid
Immunoprecipitation

answered Mar 13 '12 at 01:00

jp89

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jp has a good point - technically there is no 'hydrophobic force' but when computations are done, a hydrophobic term is often made in the calculations. – shigeta Mar 13 '12 at 04:10
Although hydrophobicity isn't a "force", shouldn't it still be included in the answer (creates an entropic advantage)? – LanceLafontaine Aug 17 '12 at 02:22