Depends totally on what tools your local bike thief is carrying at that moment.
If the miscreant has a jack/ram then the U lock can be forced apart quietly in a minute.
If the blaggard has an angle grinder, both a chain and U lock can be cut, but it's noisy and obvious. The chain will need to be held in one hand while cutting with the other, and the black nylon outer sock may create a snagging hazard.
A common tool for the discerning light-finger is the large folding bolt-cutters, where a 36" or 48" unit can fold up to about half that and be concealed under a jacket. These are also mostly silent and can cut most chain on the lower end of the spectrum They can even cut cheaper U locks.

From https://www.rakdistribution.net/36-inch-folding-bolt-cutters
One U lock can't secure the front wheel to the frame at the same time as the rear wheel, so you need something else. A chain helps extend the range of your locks. Two U locks might work well also, but they may not reach around fixed locking points like a rack or a wall shackle. A fence post or tree would be right-out.
Every bike can be stolen eventually, regardless of how many locks you put on. Your best options are to make it less-attractive, or take the bike inside with you.