I found a file of size 1 GB in /vm/swapfile0, that has not been accessed in a long time, according to last access date value in ls -l.
My assumption is, that this file is left over from an older macOS version. The last access was probably before I upgraded to 10.12. Can I safely remove it?
I also found some files of size 1 GB in /private/var/vm. These have recent access times; both sleepimage and swapfile1 today and swapfile0 two weeks in the past. I think these are in active use.
One side question though: sleepimage has a size of 1 GB, although I have 4 GB RAM installed. How is that possible? Other threads on the topic of sleepimage suggested that the size would match that of the RAM installed in my Mac.