I am using PowerPoint from Microsoft Office 2016. I use a lot of screenshots (save the screenshot to clipboard and paste it in PowerPoint). When using the retina display, the presentation file size becomes a lot bigger compared to the same task using a normal display. That makes sense, since the same size images would be 4X as many pixels.
There seems to be a solution. You can go to File > Compress Pictures. However, I don't think that compresses the images properly. I can set the resolution to a very low setting. That makes the images very blurry and the file size is reduced. However, the file size it still much higher than using non-retina images without any compression. The non-retina presentation is smaller file and better quality in the end. I think that the way PowerPoint calculates the resolution, that still somehow does not take into account the retina conversion by the OS.
Is there a way to use PowerPoint with a retina display, but still keep the images to a reasonable size? Can I keep PowerPoint in non-retina mode somehow?
Looking at previous posts, there used to be an option to "Open in low resolution" in File > Get Info, but that does not seem to exist anymore.

typekey doesn't exist in the com.apple.screencapture.plist file. Actually the com.apple.screencapture.plist file doesn't exist at all, by default. So if one has changed the type to be saved as JPG files, the proper way to revert back to the default setting isdefaults delete com.apple.screencapture type;killall SystemUIServernot changing the type from JPG to PNG in the command. – user3439894 Sep 06 '16 at 23:21